染色体12p13的rs12425791位点基因多态性与急性缺血性卒中短期预后的关系

摘要

目的：探讨染色体12p13的rs12425791位点基因多态性与急性缺血性卒中（AIS）短期预后（1年）的关系。方法选择401例AIS患者，运用PCR-RFLP法检测染色体12p13的rs12425791位点基因型，患者出院后随访1年，观察患者死亡和再发缺血性卒中情况。运用Logistic回归模型分析个体基因型和脑卒中预后的关系。结果401例AIS患者中，有31例发生死亡和复发卒中。在校正了年龄、性别和病史等因素后，Logistic回归分析结果显示，rs12425791纯合子突变（AA型基因）的AIS患者1年内发生死亡或再发卒中的危险度较高，是GG型基因患者的2．602倍（95％CI1．216～5．564）。结论染色体12p13的rs12425791位点纯合子突变是AIS患者短期预后不良的独立危险因素。%Objective To investigate the association between genetic variants of rs 12425791 on chromosome 12p13 and the one year risk of stroke-related death or recurrent stroke following initial stroke .Methods A total of 401 acute ischemic stroke(AIS) patients who had first-ever ischemic stroke were analyzed .The genotypes of chromosome 12p13 rs12425791 were analyzed by PCR-RFLP .Logistic regression analysis was used to assess the effect of individual genotype on stroke-related mortality or recurrent stroke in one year .Results Among the 401 AIS patients ,31 died or developed a recurrent stroke .After adjustment for age ,sex and vascular risk factors ,logistic regression analysis indicated that the odd ratio were 2 .602(95% CI 1 .216-5 .564) for individuals with homozygous variant allele of rs12425791 .Conclusion This study found that genetic variants of rs12425791 on chromosome 12p13 are independent predictors of stroke-related mortality or stroke recurrence in patients with incident ischemic stroke .