广西汉族人群NINJ2基因单核苷酸多态性位点rs12425791与缺血性脑卒中的关系

摘要

Objective To investigate the relationship between NINJ2 gene single nucleotide polymorphism (SNP) rsl2425791 and ischemie stroke (IS) in Guangxi Han population. Methods The genotype of NINJ2 gene SNP rsl2425791 in 166 IS patients (IS group) and 192 healthy controls (normal control group) were examined by TaqMan MGB genutyping assays. The frequencies of genotype and alleles between the two groups were compared. Results There was no significant difference of genotype frequencies of N1NJ2 gene SNP rs12425791 between IS group [ G/G 103 ( 62. 05% ) , G/A 54 ( 32. 53% ) , A/A 9 (5. 42% ) ] and normal control group [ G/G 112 (58.33%), G/A 65 (33. 85%), A/A 15(7.81%)] (χ2=1.011, P = 0. 603 ). And there was no significant difference of allele frequencies of NINJ2 gene SNP rsl2425791 between IS group ( G 78. 31% , A 21. 69% ) and normal control group ( G 75. 26% , A 24. 74% ) (χ2= 0. 928, P= 0. 335 ) . Conclusion NINJ2 gene SNP rs 12425791 may be no signiiicant association with the onset of IS in Guangxi Han population.%目的 探讨广西汉族人群NINJ2基因单核苷酸多态性(SNP)位点rs12425791与缺血性脑卒中(IS)的关系.方法 采用TaqMan MGB探针等位基因分型技术,对166例IS患者(IS组)和192名健康对照者(正常对照组)NINJ2基因SNP位点rs12425791进行基因分型,对两组基因型和等位基因频率进行比较.结果 IS组NINJ2基因SNP位点rs12425791基因型分布[G/G型103例(62.05％),G/A型54例(32.53％),A/A型9例(5.42％)]与正常对照组[G/G型112例(58.33％)、G/A型65例(33.85％)、A/A型15例(7.81％)]比较差异无统计学意义(x2=1.011,P=0.603).IS组NINJ2基因SNP位点rs12425791等位基因频率(G等位基因78.31％,A等位基因21.69％)与正常对照组(G等位基因75.26％,A等位基因24.74％)比较差异亦无统计学意义(x2=0.928,P=0.335).结论 广西汉族人群NINJ2基因SNP位点rs12425791可能与IS的发病无关.