广西壮族自治区壮族人群MACROD2基因rs2208454位点单核苷酸多态性与缺血性脑卒中发病的关系

摘要

目的 探讨广西壮族自治区壮族人群MACROD2基因rs2208454位点单核苷酸多态性(SNP)与缺血性脑卒中(IS)发病的关系.方法 采用SNaPshot法对101例广西壮族IS患者(IS组)及104例健康体检者(对照组)的MACROD2基因rs2208454位点单核苷酸进行检测分析.结果 两组MACROD2基因rs2208454位点GG、GT、TT基因型及G、T等位基因分布相比,P均>0.05;在显性(TT+GT和GG)、隐性(TT和GT+GG)及加性(TT和GG)三种遗传模型下,MACROD2基因rs2208454位点SNP与IS患病风险无关联(P均>0.05).结论 广西壮族人群MACROD2基因rs2208454位点SNP与IS发病可能不相关.%Objective To explore the relationship between single nucleotide polymorphism (SNP)of rs2208454 in MACROD2 gene and ischemic stroke (IS)in Zhuang population of Guangxi Zhuang autonomous region. Methods The rs2208454 single nucleotide of MACROD2 gene was detected by SNaPshot technique in 101 cases of Guangxi Zhuang IS pa-tients (IS group)and 104 healthy subjects (control group). Results The GG,GT,TT genotypes and G,T allele distri-bution of rs2208454 locus of MACROD2 gene were not statistically different between these two groups (all P > 0. 05). The rs2208454 locus SNP of MACROD2 gene was not associated with the risk of IS in dominant (TT + GT and GG),recessive (TT and GT + GG)and additive (TT and GG)genetic models (all P > 0. 05). Conclusion The rs2208454 locus SNP of MACROD2 gene has no correlation with the pathogenesis of IS in Guangxi Zhuang population.