动脉粥样硬化性肾动脉狭窄与冠状动脉病变及外周血管病变关系的Meta分析

摘要

Objective To systematically evaluate the relationship between atherosclerotic renal artery stenosis (ARAS) and cor‐onary artery disease (CAD) and peripheral arterial disease (PAD) .Methods We gathered all case‐control studies about the correla‐tion of ARAS with CAD and PAD in the following databases:Cochrane library ,PubMed ,EMBASE ,Web of science until April , 2014 .Two reviewers extracted all relevant datas from the screened documents independently according to exclusion and inclusion criteria ,RevMan 5 .2 software were used to conduct Meta‐analysis .Results Fourteen trials were included .Meta‐analysis showed that :the OR (95% CI)of CAD with 1 vascular lesions ,2 vascular lesions ,3 vascular lesions and left main stenosis ,PAD and ARAS were 0 .70(0 .59-0 .82) ,1 .28(1 .10 -1 .48) ,2 .09(1 .69 -2 .59) ,1 .82(1 .40 -2 .36) ,3 .68(2 .21 -6 .10) with statistical signifi‐cance (P<0 .05) .Conclusion CAD with 2 vascular lesions ,3 vascular lesions and left main stenosis ,PAD were connected with ARAS ,CAD with 1 vascular lesions has little relationship with ARAS .%目的：系统评价动脉粥样硬化性肾动脉狭窄（ARAS ）与冠状动脉病变（CAD）及外周血管病变（PAD）的关系。方法通过计算机文献检索Cochrane图书馆、PubMed、EMBASE、Web of science ，检索自建库至2014年4月发表的所有关于ARAS与CAD及PAD关系的病例对照研究，由2名研究者独立按照文献纳入及排除标准筛选文献并提取数据，采用RevMan5．2统计软件进行Meta分析。结果共纳入14篇文献，分析显示CAD中1支血管病变、2支血管病变、3支血管病变、左主干病变（LMCA）及PAD与ARAS的OR（95％ CI）分别为0．70（0．59～0．82）、1．28（1．10～1．48）、2．09（1．69～2．59）、1．82（1．40～2．36）、3．68（2．21～6．10），差异均有统计学意义（P＜0．05）。结论 CAD中2支血管病变、3支血管病变、左主干病变及 PAD与 ARAS相关，而CAD中1支血管病变与ARAS关系不大。