ALR在急性肾损伤早期诊断中的价值评估及临床意义

摘要

Objective To explore whether augmenter of liver regeneration (ALR) can serve as early diagnostic biomarker in the patients with acute kidney injury(AKI).Methods The inpatients with possibility to AKI in the central ICU of Second Affiliated Hospital of Chongqing Medical University from October 2014 to October 2015 were recruited and assigned to the AKI group and non-AKI group according to the KDIGO guidance.Blood and urine ALR and blood creatinine were detected at 0,6,12,24,48,72 h after entering the group.Results Among all cases,40 cases(62.5％) developed to AKI.Blood ALR and urine ALR at 6h after entering the group in the AKI group began to significantly increase compared with the non-AKI group(P＜0.05),the blood and urine ALR levels reached to the peak value at 12,24 h after entering the group;the blood creatinine level at 12 h after entering the group in the AKI group began to significantly increase compared with the non-AKI group(P＜0.05),blood creatinine level was still slowly and progressively elevated at 72 h after entering the group.Conclusion Serum and urine ALR levels are significantly increased in the early stage of AKI,which indicates that ALR may be a new type biomarker for diagnosing AKI.%目的 本研究拟探讨肝再生增强因子(ALR)是否可作为急性肾损伤(AKI)患者的早期诊断生物标志物.方法 将2014年10月至2015年10月在重庆医科大学附属第二医院中心ICU住院且有发展为AKI可能的患者收集入组,按照美国肾脏病基金会(KDIGO)指南将患者分为AKI组及非AKI组,检测入组后0、6、12、24、48、72 h患者的血、尿ALR及血肌酐水平.结果 所有患者中,40例患者发展成AKI.AKI组患者血ALR和尿ALR水平在入组后6h开始较非AKI组均有明显上升(P＜0.05),血、尿ALR水平分别在入组后12、24 h达到峰值;AKI组患者血肌酐水平在入组后12 h开始较非AKI组明显上升(P＜0.05),血肌酐于入组后72 h仍缓慢进行性升高.结论 血、尿ALR水平在AKI早期就明显上升,提示ALR有可能是一种诊断AKI的新型生物标志物.