目的：研究婴幼儿维生素D缺乏性佝偻病与反复呼吸道感染之间的关系。方法236例反复呼吸道感染患儿为观察组，并随机抽取108例体检婴幼儿为对照组，观察两组研究对象维生素D缺乏性佝偻病发病率，并比较两组研究对象血清25羟基维生素D3[25-（OH）D3]、碱性磷酸酶（AKP）浓度，研究反复呼吸道感染与维生素D缺乏性佝偻病的关系。结果观察组佝偻病发病69例（29．2％），维生素D亚临床状态48例（20．3％），对照组佝偻病发病16例（14．8％），维生素D亚临床状态29例（27．4％），两组的发病率有统计学差异（χ2＝11．22，P＜0．05）；观察组25-（OH）D3、IgG、IgM、IgA均低于对照组，AKP高于对照组，差异均具有统计学意义（t值分别为14．18、8．74、16．73、1．67、4．11，均P＜0．05）。结论婴幼儿维生素D缺乏性佝偻病与反复呼吸道感染关系密切，预防性补充维生素D是提高婴幼儿免疫功能以及预防反复呼吸道感染发生的有效途径。%Objective To study the relationship between vitamin D deficiency rickets and recurrent respiratory tract infection in infants. Methods Totally 236 cases of recurrent respiratory tract infection were chosen in observation group, and 108 infants receiving physical examination were randomly selected in control group.The incidence of vitamin D deficiency rickets was observed in two groups, and serum 25 (OH)D3 and alkaline phosphatase (AKP) concentrations were compared between two groups.Results In the observation group rickets were found in 69 cases (29.2%) and vitamin D sub clinical state in 48 cases (20.3%), while in the control group there were 16 cases (14.8%) and 29 cases (27.4%), respectively.The incidence in two groups was significantly different (χ2 =11.22,P <0.05). Compared with the control group, serum 25 ( OH) D3 , AKP, IgG and IgA concentrations in the observation group were lower but AKP concentration was higher with significant difference (t value was 14.18, 8.74, 16.73, 1.67 and 4.11, respectively, all P<0.05). Conclusion Infants vitamin D deficiency rickets is closely related with recurrent respiratory tract infection.Preventive supplementation of vitamin D is an effective way to improve infant immune function and prevent recurrent respiratory tract infection.
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