Objective To explore the influence of latency period of preterm premature rupture of membranes before 34 weeks on perinatal outcomes so as to provide evidences for termination of pregnancy in time.Methods Totally 220 singleton pregnant women with preterm premature rupture of membranes who delivered at 28 to 33 +6 weeks of pregnancy in Children's Hospital of Hebei Province during January 2008 to December 2014 were selected.According to the gestational weeks and latency period,they were divided into 8 groups.The gestational weeks in group A was 28 to 31 +6 weeks (108 cases) and in group B was 32 to 33 +6 weeks (112 cases).In group A1,there were 15 cases and in group B1,there were 27 cases.The latency period of these two groups was less than 24h.In group A2,there were 26 cases and in group B2 there were 40 cases.The latency period of the two groups was not less than 24h but less than 72h.In group A3,there were 48 case and in group B3,there were 36 cases.The latency period of two groups was not less than 72h but less than 168h.In group A4,there were 19 cases and in group B4,there were 7 cases.The latency period of two groups was not less than 168h.The general data and maternal and infant complications of each group were analyzed statistically.Results Latency periods of cases who were pregnant for 28 to 31 +6 weeks were longer than those of cases who were pregnant for 32 to 33 +6 weeks,and there was significant difference in two groups (x2 =4.32,P =0.04).More pregnancy weeks,oligohydramnios,intrauterine infection and nulliparity were associated with short latency period.When the latency period was more than 72 hours,the incidence rates of chorioamnionitis and early neonatal infection increased,while premature complications declined and the length of stay in NICU was shortened.Conclusion Latency period is an important factor of perinatal outcomes of preterm premature rupture of the membrane before 34 weeks.Prolonging latency period,actively completing treatment to improve fetal lung maturity and preventing infection will effectively improve the prognosis of mother and premature infant.Latency period of women who are pregnant for 28 to 31 +6 weeks with preterm premature rupture of membranes should be prolonged 72 hours or more as much as possible.Latency period of women who are pregnant for 32 to 33 +6 weeks with preterm premature rupture of membranes should be prolonged properly 48 hours or more.%目的 探讨＜34周胎膜早破期待治疗时限对母婴结局的影响,为适时终止妊娠提供依据.方法 选取2008年1月至2014年12月间在河北省儿童医院产科住院分娩的28 ～33+6周胎膜早破单胎孕妇220例.按孕周大小和潜伏期时限分为8个组,分别为108例孕28 ～ 31+6周为A组,112例孕32 ～33+6周为B组.潜伏期＜24h:A1组15例,B1组27例;潜伏期≥24h～＜72h,A2组26例,B2组40例;潜伏期≥72h ～＜168h,A3组48例,B3组36例;潜伏期≥168h,A4组19例,B4组7例.对各组孕妇的一般资料和母婴并发症进行统计学分析.结果 妊娠28 ～31+6周潜伏期时限长于妊娠32 ～33+6周,A、B组差异有统计学意义(x2=4.32,P =0.04);大孕周、羊水过少、宫内潜在感染、未产等因素与短潜伏期相关.潜伏期时限超过72h,绒毛膜羊膜炎发生率、新生儿早期感染率升高,但早产儿并发症降低,入住NICU时间缩短.结论 延长潜伏期时限,积极完成促胎肺成熟治疗,预防感染,将有效改善母婴预后;妊娠28 ～31+6周胎膜早破孕妇,尽可能延长潜伏期72h以上;妊娠32～33+6周胎膜早破孕妇,适当延长潜伏期48h以上.
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