气体信号分子硫化氢调节细胞功能的作用与机制

摘要

BACKGROUND:There are an increasing number of studies addressing hydrogen sulfide as the third gaseous signal molecule, to regulate cellular function, but some contradictions emerge. n OBJECTIVE:To summarize the mechanism of hydrogen sulfide regulating cellfunction based on the current researches. n METHODS:A computer-based online search of the PubMed database (from 1990 to 2013) was performed, with the key words of“hydrogen sulfide, gasotransmitter”in English. Final y 54 related articles were included in the result analysis. n RESULTS AND CONCLUSION:Accumulating evidence has highlighted the contribution of hydrogen sulfide on regulating cellfunction, and the underlying mechanism is very complex. Traditional signal molecule (such as estrogen and neuromediators) may amplify the signals for signal transduction through a series of cascade reaction, but the gaseous signal molecule promotes cellmetabolism through the post-transcriptional modification of intracellular target protein. The majority of studies indicate that hydrogen sulfide plays an antioxidant, anti-inflammatory and anti-apoptotic role in the physiological concentration, but there are some contradictions in terms of inflammation and apoptosis research. Therefore, further study on the mechanism of hydrogen sulfide should be implemented.%背景：硫化氢作为第3种气体信号分子在细胞功能调节方面的研究越来越多，但是目前对其认识尚存在一些矛盾之处。n　　目的：总结硫化氢在细胞功能调节方面的作用机制及其研究进展。n　　方法：应用计算机检索1990至2013年PubMed数据库，以“hydrogen sulfide,gasotransmitter”为检索关键词进行检索，最终纳入54篇相关进行分析。n　　结果与结论：很多研究证明硫化氢在细胞功能的调节方面起到重要作用，其在细胞功能调节方面的作用机制较为复杂。传统的信号分子(如激素和神经介质)可通过一系列的级联反应来放大信号进行信号转导，但是气体信号分子可通过转录后修饰胞内靶向蛋白而更迅速的影响细胞代谢。大多数研究表明生理浓度下的硫化氢具有抗氧化、抗炎和抗凋亡的作用。但在炎症和凋亡方面的研究，部分研究却得到了不同的结果，也说明硫化氢对于某些细胞功能的调节可能存在双重性，因此对其作用机制的研究有待进一步加强。