Enphytosine kinase variant, isolated nucleic acid molecule, methods of detecting an agent capable of modulating the interaction of fosk with sphingosine kinase and an agent capable of binding or differently associating with the amino acid defined sphingosine kinase region 16-153 for the analysis, projection and / or modification of an agent capable of interacting with the sphingosine kinase region defined by amino acids 16-153 and modulating at least one functional activity associated with said sphingosine kinase cellular functional activity in a mammal and treatment and / or prophylaxis of a condition in a mammal, agent, use of a sphingosine kinase variant, and pharmaceutical composition

摘要

"Sphingosine kinase variant, isolated nucleic acid molecule, methods of detecting an agent capable of modulating FOSK interaction with sphingosine kinase and an agent capable of binding to or differentiating from sephosine kinase AMINO ACIDS 16-153 FOR ANALYSIS, DESIGN AND / OR MODIFICATION OF AN AGENT ABLE TO INTERACT WITH THE REGION OF SPHINGOSINE KINASE DEFINED BY Amino acids 16-153 AND MODULATION OF AT LEAST ONE FUNCTIONAL ACTIVITY ASSOCIATED WITH COSAIN MODULATION Of Cellular Functional Activity in a Mammalian and Treatment and / or Prophylaxis of a Condition in a Mammalian, Agent, Use of a Sphingosine Kinase Variant and Pharmaceutical Composition ". The present invention generally relates to a sphingosine kinase variant and its derivatives, analogs, imitations and chemical equivalents exhibiting reduced catalytic activity, and more particularly to sphingosine kinase variants which exhibit reduced ability to phosphorylate sphingosine at sphingosine-1-phosphate. The present invention also contemplates genetic sequences encoding said sphingosine kinase variants and derivatives and their analogs and imitations. The variants of the present invention are useful in a variety of therapeutic and prophylactic applications.