Molecular mechanisms of regulatory T cell -mediated rapid suppression in human conventional T cell signalling monitored by phosphoproteomics

摘要

1. This rst phosphoproteomics study on primary T-cells directly suppressed by Tregs reveals a rapid downregulation of phosphorylation on several proteins. 2. A large group of the 29 signicantly regulated phosphoproteins can be mapped to a functional cluster involving RNA processing. 3. The role of the phosphorylated proteins in Treg suppression will be veried with complementary methods, like siRNA knockdown.