BACKGROUND: Many studies have shown that different types of anterior cervical surgery in the treatment of two-level contiguous cervical disc herniation can obtain satisfactory results, but which method is the best has not yet reached a consensus. OBJECTIVE: To compare the efficacy and safety of three types of anterior cervical surgery for treating two-level contiguous cervical disc herniation. METHODS: We retrospectively analyzed clinical data of 62 patients with two-level contiguous cervical disc herniation who underwent anterior decompression and fusion. These patients were assigned to three groups. Bone graft group received anterior cervical discectomy with autogenous iliac bone graft fusion. Titanium mesh group received anterior cervical corpectomy with titanium mesh fusion. Cage group received anterior cervical discectomy with cage fusion. Fusion rate of bone graft and improvement of neurological function (Japanese Orthopaedic Association Scores) were evaluated and compared after treatment in the three groups. Cervical vertebra anteroposterior and lateral images were used to measure height of anterior and posterior margin of vertebral body and Cobb angle changes of fusion segment. RESULTS AND CONCLUSION: Al 62 patients were fol owed up and the fol ow-up time was ranged from 8 to 30 months. Operation time was significantly longer in the bone graft group than in the titanium mesh and Cage groups (P < 0.05). Intraoperative blood loss was larger in the bone graft group than in the titanium mesh and Cage groups (P < 0.05). Japanese Orthopaedic Association Scores were significantly improved after treatment (P < 0.05). No significant difference was found at different time points (P > 0.05). The fusion rate of bone graft was higher in the bone graft group than in the titanium mesh and Cage groups (P < 0.05) at 3 months after treatment, and bone union was found in the final fol ow-up. Height of anterior and posterior margin of vertebral body was significantly increased after treatment (P < 0.05). No significant difference in the increase of the height of anterior margin was detected among the three groups (P > 0.05). The increase in the height of posterior margin was higher in the Cage group than in the bone graft group and titanium mesh group (P < 0.05). Vertebral height loss of the anterior margin was higher in the bone graft group than in the titanium mesh and Cage groups, but vertebral height loss of the posterior margin was highest in the bone graft group, fol owed by titanium mesh group and Cage group at 3 months after treatment (P < 0.05). The increase value of Cobb angle was higher in the titanium mesh group than in the bone graft group and Cage group (P < 0.05). At 3 months after treatment, the altered value of Cobb angle was highest in the bone graft group, fol owed by titanium mesh group and Cage group (P < 0.05). No significant difference in the height of anterior and posterior margins of the vertebral body and Cobb angle was detectable between final fol ow-up and 3 months post-treatment (P > 0.05). These findings indicated that the three kinds of fusion method for treating two-level contiguous cervical disc herniation could obviously lessen nervous systems and improve cervical vertebra functions. In the bone graft group, operation time was long. Intraoperative blood loss was more. Postoperative height loss of the posterior margin of the vertebral body was visible. Cervical lordosis could be easily induced. Compared with the bone graft group, titanium mesh and Cage groups could better maintain the height and curvature of the cervical vertebra, but the Cage group had apparent advantages.%背景：研究证实前路不同减压融合方法修复连续双节段颈椎间盘突出症均可取得满意疗效，但哪种方案效果最佳目前尚无统一意见。目的：比较颈椎前路3种减压植骨融合内固定方案修复连续双节段颈椎间盘突出症的有效性及安全性。方法：回顾分析连续双节段颈椎间盘突出症并行前路减压融合内固定62例患者的临床资料，根据修复方案分为3组，单纯植骨组行前路椎间盘切除髂骨植骨内固定，钛网组行前路椎体次全切钛网植骨内固定，Cage组行前路椎间盘切除 Cage 植骨内固定。分别对3组患者治疗后植骨融合率及神经功能改善情况(日本骨科学会 JOA 评分)进行评估对比，并行颈椎正侧位片 X 射线检查以测量椎体前后缘高度及融合节段的 Cobb角变化。结果与结论：62例患者均获得随访，随访时间8-30个月。单纯植骨组手术时间较另两组长(P <0.05)，术中出血量较另两组大(P <0.05)。治疗后 JOA 评分较治疗前明显改善(P <0.05)，不同随访时期组间差异无显著性意义(P >0.05)。治疗后3个月植骨融合率单纯植骨组>钛网组及 Cage 组(P <0.05)，末次随访时均骨性愈合。治疗后融合节段椎体前后缘高度较治疗前明显增加(P <0.05)，前缘高度增加量3组间差异无显著性意义(P >0.05)；后缘高度增加量 Cage 组大于单纯植骨组及钛网组(P <0.05)。治疗后3个月椎体前缘高度丢失单纯植骨组>钛网组及 Cage 组，后缘高度丢失单纯植骨组>钛网组> Cage 组(P <0.05)。颈椎融合节段 Cobb角增加值钛网组大于单纯植骨组及 Cage 组(P <0.05)，治疗后3个月 Cobb 角变化量单纯植骨组>钛网组>Cage 组(P <0.05)。末次随访椎体前后缘高度、Cobb 角与治疗后3个月的差值组间差异均无显著性意义(P >0.05)。提示3种植骨融合方法修复连续双节段颈椎间盘突出均可以明显缓解神经症状，改善颈椎功能。单纯植骨组手术时间长，术中出血量多，治疗后椎体后缘高度丢失明显，容易造成颈椎前凸。与单纯植骨组相比钛网组和 Cage 组能更好的维持颈椎高度与曲度，但 Cage 组优势更明显。
展开▼
