Four (S)-β-substituted-α-aminoacids, with yield of 60%~75% and ee of 90%~95%, were synthesized by the reaction of aldol hydroxymethylation, dehydrolation, Michael nucleophilic addition and acidolysis, then isolated by cation exchange resine.The structures were confirmed by 1H NMR and elemental analysis.%以2-[N-(N′-苄基-L-脯氨酰)氨基]二苯甲酮的甘氨酸席夫碱Ni(Ⅱ)配合物为原料,经Aldol 羟甲基化,脱水,Michael加成和水解反应及离子交换层析,合成了4个(S)-β-取代-α-氨基酸衍生物,产率60%~75%, ee值90%~95%,其结构经1H NMR和元素分析确证.
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