Michael Addition Reactions between Nucleophilic Glycine Equivalents and Acrylic Acid Derivatives as a Practical and Generalized Approach to the Asymmetric Synthesis of β-Substituted-α-Amino Acids

摘要

Asymmetric Michael addition reactions between chiral/achiral nucleophilic glycine equivalents and chiral/achiral acrylic acid derivatives have been developed for the truly practical preparation of β-substituted pyroglutamic acids. The conceptually novel idea of the topographical control of the stereochemical outcome of asymmetric reactions, as a theoretical background of this chemistry is also described.