Michael Addition Reactions between Nucleophilic GlycineEquivalents and Acrylic Acid Derivatives as a Practicaland Generalized Approach to the Asymmetric Synthesisof II-Substituted-a-Amino Acids

摘要

Asymmetric Michael addition reactions between chiral/achiralnucleophilic glycine equivalents and chiral/achiral acrylic acidderivatives have been developed for the truly practicalpreparation of n-substituted pyroglutamic acids. The con-ceptually novel idea of the topographical control of thestereochemical outcome of asymmetric reactions, as atheoretical background of this chemistry is also described.