Objective To study the effect of stilbene on blood glucose of rats with type 2 diabetes. Methods 50 male Wistar rats were randomly divided into model group (n=40) and control group (n=10). The model group was given fat emulsion 40 days continuously with 20m1/kg, po, and streptozotocin with 120 mg/kg on the 41st day, 100 mg/kg on the 42nd day, i.p. After the modeling, the model group was divided into 4 groups with 10 in each. They were given stilbene with 500 ml/kg, 200 ml/kg, 100 ml/kg and metformin with 100 mg/kg, ip, respectively. The level of blood glucose, blood lipid and glycogen content were determined. Results After the modeling, the blood glucose and TG, TC, LDL-C, HDL-C increased by 140.89％, 25.77％, 275.52％, 105.54％ and 31.25％ respectively (P＜0.01); after stilbene was given, the level of blood glucose and lipid decreased significantly (P＜0.05), the liver glycogen content increased significantly by 8.06％～16.17％ compared to the control group. Conclusion Stilbene can decrease the concentration of blood glucose and lipid, and increase the liver glycogen content of rats with type 2 diabetes.%目的 探讨二苯乙烯对2型糖尿病降血糖作用.方法 50只Wistar雄性大鼠随机分为模型组((n=40)和对照组(n=10).模型组大鼠口服脂肪乳加ml/kg,连续40 d,分别在第41、42天时模型组大鼠腹腔注射链脲佐菌素120 mg/kg,100 mg/kg,各1次.建立模型后,将模型组大鼠随机分为4组,每组10只.分别灌胃给予二苯乙烯500 mg/kg、200 mg/kg、100 mg/kg和二甲双胍100 mg/kg.全自动生化分析仪测定血糖、血脂水平;分光光度计测肝糖元含量.结果 建模后,大鼠的血糖(Glu)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C),高密度脂蛋白(HDL-C)水平分别升高140.89%、25.77%、275.52%、105.54%和31.25%(P<0.01);给予模型组大鼠二苯乙烯20 d后,血糖和血脂水平比给药前降低(P<0.05),肝糖元含量比对照组增加8.06%～16.17%.结论 二苯乙烯具有降低2型糖尿病大鼠血糖和血脂、增加肝糖元含量的作用.
展开▼
