Hypoglycemic Effects of Endotoxin in Eviscerated Dogs.

摘要

Terminal endotoxin shock in the canine is associated with profound hypoglycemia. In order to evaluate the intricacies of this response during endotoxin shock, serum glucose and insulin levels were measured in eviscerated dogs with ablation of pancreatic and hepatic function. The response of eviscerated dogs with absent pancreatic and hepatic function is compatible with insulin-independent peripheral tissue catabolism of glucose and an increased lactate/pyruvate ratio suggests anaerobic metabolism. Increased survival in animals administered exogenous glucose indicates reversible, fuel dependent changes of peripheral tissue metabolism. Since hyperglycemia has been a predominant finding in clinical endotoxin shock, species differences are emphasized but perhaps closer scrutiny of the terminal stages of clinical endotoxin shock would be more compatible with this experimental model.