产后抑郁症患者正性和负性音乐刺激下情绪反应及脑激活特征

摘要

目的 探讨产后抑郁症患者正、负性音乐刺激下的情绪反应及脑激活特征.方法 选取符合DSM-Ⅳ产褥期抑郁症诊断标准且爱丁堡产后抑郁量表评分≥9分的11例产后抑郁症患者(抑郁症组)和11名产后对照者(对照组),在正、负性音乐刺激下进行脑功能磁共振扫描,比较两组被试者的主观愉悦度评价(人像自评系统量表评分)和脑功能磁共振扫描激活脑区的差异.结果 抑郁症组对正、负性音乐的主观愉悦度评价[分别为:(6.23±1.01)、(3.08±0.64)分]均低于对照组[分别为:(7.00±0.63)、3.72 ±0.47)分],差异有统计学意义(t=-2.27,P=0.03;t=-2.79,P=0.01).在负性刺激下,与对照组相比,抑郁症组患者表现为海马的激活增强,并且右侧海马的激活与主观愉悦度评价水平呈负相关.结论 产后抑郁症患者对负性音乐的愉悦度评价更低,其可能与右侧海马的异常激活有关.%Objective To explore the neural activity of females with post-partum depression in response to negative and positive emotional music and further to examine the relationship between the psychological pleasure levels and the abnormal neural activity in post-partum depression.Methods Eleven postpartum healthy females and 11 unmediated depressed females underwent functional magnetic resonance imaging blood-oxygen-level-dependent acquisition during a block-designed emotional music.Results The depressed females showed lower pleasure levels both to the positive and negative music(6.23 ± 1.01,3.08 ± 0.64,respectively) than healthy ones (7.00 ± 0.63,3.72 ± 0.47,respectively),the difference was statistically significant(t =-2.27,P =0.03 ; t =-2.79,P =0.01).Postpartum depression patients exhibited significantly stronger hippocampus activation than the healthy subjects and there was a significant negative correlation between right hippocampus activity and psychological pleasure levels to negative music.Conclusion Postpartum depressied females may have lower pleasure levels to negative music,which may be related to the abnormal activation of the right hippocampus.