阿托伐他汀对急性缺血性脑卒中患者血清hs-CRP TNF-α的影响

摘要

Objective To investigate the effects of atorvastatin on the serum hs‐CRP and TNF‐αlevels of patients with a‐cute ischemic stroke (AIS).Methods 76 patients with AIS were divided into light group ,medium group and heavy group ac‐cording to clinical neurological impairment score standards. 30 healthy volunteers were considered as control group. 76 patients with AIS were divided into conventional group (treated with conventional therapy) and atorvastatin group (treated with atorv‐astatin). The serum hs‐CRP ,TNF‐αlevels of two groups were compared.Results The serum hs‐CRP and TNF‐αlevels in pa‐tients with AIS were significantly higher than these in control group. The heavier the neurological function impairment of pa‐tients with AIS was ,the higher the serum hs‐CRP and TNF‐αlevels were. The serum hs‐CRP and TNF‐αlevels of atorvastatin group were lower than these of control group.Conclusion The serum levels of CRP and TNF‐αof patients with AIS can reflect patients’ illness degree ,and atorvastatin can effectively inhibit inflammatory cytokine levels to improve the patients’ progno‐sis.%目的：探讨急性缺血性脑卒中（AIS）患者血清hs‐CRP、TNF‐α的变化及阿托伐他汀的干预作用。方法选择76例A IS患者为研究对象，根据临床神经功能缺损程度评分标准分为轻型组、中型组及重型组，30例健康体检者纳入对照组，比较各组患者血清hs‐CRP、TNF‐α水平；随机将76例患者分为2组，常规组予抗血小板等常规治疗，他汀组联合阿托伐他汀治疗，比较治疗前后2组血清hs‐CRP、TNF‐α水平的变化。结果轻型组、中型组、重型组AIS患者血清hs‐CRP及TNF‐α水平均明显高于对照组（P＜0.05），且轻型组、中型组、重型组AIS患者血清hs‐CRP及TNF‐α水平依次升高（P＜0.05）；治疗后他汀组与常规组患者血清hs‐CRP及TNF‐α水平均有明显下降（P＜0.05），且上述指标他汀组明显低于常规组（P＜0.05）。结论急性缺血性脑卒中患者血清hs‐CRP及TNF‐α水平可反映患者病情严重程度，而阿托伐他汀可有效抑制AIS患者的炎症因子水平，进而改善患者预后。