利奈唑胺与万古霉素治疗耐甲氧西林金黄色葡萄球菌肺炎患者的疗效对比

摘要

目的 探讨利奈唑胺与万古霉素治疗耐甲氧西林金黄色葡萄球菌(MRSA)肺炎的疗效及不良反应发生率.方法 将39例MRSA感染肺炎患者按治疗方案分为两组,观察组21例给予利奈唑胺治疗,对 照组18例给予万古霉素治疗.比较两组患者的治疗效果及不良反应.结果 观察组的治疗效果显著优于对照组,两组比较差异有统计学意义(P＜0.05).观察组的不良反应发生率显著低于对照组,两组比较差异有统计学意义(P＜ 0.05).结论 利奈唑胺治疗MRSA感染肺炎疗效好、不良反应发生率低,可以用于MRSA感染肺炎的首选治疗药物.%Objective To investigate the effect and adverse reaction of linezolid and vancomycin in treating meticillin resistant staphylococcus aureus (MRSA) in patients with pneumonia.Methods Thirty-nine MRSA patients with pneumonia were divided into two groups according to treatment programs,21 cases in observation group were given the linezolid treatment,and 18 cases in the control group were given the vancomycin treatment.The effect and adverse reaction of the two groups were compared.Results The effect of the observation group was significantly better than that of the control group,the differences were significant (P ＜ 0.05 ).The adverse reactions of observation group was significantly lower than that of the control group,the differences were significant(P ＜ 0.05 ).Conclusions Linezolid has good curative effect and low adverse reaction incidence for treating MRSA pneamonia,can be used as the preferred therapy for MRSA pneumonia.