血清PCT、LAC水平检测在糖尿病酮症酸中毒合并院内获得性肺炎患者疗效评估中的应用

摘要

Objective To investigate the application of detection of serum PCT and LAC levels in the evaluation of curative effect of patients with diabetic ketoacidosis combined with nosocomial pneu-monia . Methods The clinical data of 90 patients with diabetic ketoacidosis complicated with hospital acquired pneumonia were statistically analyzed,and these patients were used as the research group. The other 90 cases of healthy examiner were selected as control group during the same period,the serum PCT levels of two groups were detected by immunofluorescence analysis,the serum LAC levels of the two groups were detected by Hitachi 7600-120 automatic biochemical analyzer,and then the serum PCT and LAC levels of the two groups,the serum PCT and LAC levels of survival and mortality patients in the study group were statistically analyzed. Results The serum PCT and LAC levels after treatment of the study group were significantly lower than those before treatment (P < 0. 05). The serum PCT and LAC levels before treatment of the study group were significantly higher than those of the control group (P <0. 05),the differences of serum PCT and LAC levels after treatment between the two groups were not sig-nificant (P > 0. 05). Among the 90 patients,75 cases survived,15 cases died,the mortality rate was 16. 7％,the serum PCT and LAC levels of the mortality patients were significantly higher than those of the survival patients (P < 0. 05). Conclusions The application value of detection of serum PCT and LAC levels in the evaluation of curative effect of patients with diabetic ketoacidosis combined with nosoco-mial pneumonia is high.%目的 探讨血清降钙素原(PCT)、乳酸(LAC)水平检测在糖尿病酮症酸中毒合并院内获得性肺炎患者疗效评估中的应用.方法 对收治的90例糖尿病酮症酸中毒合并院内获得性肺炎患者的临床资料进行统计分析,将这些患者作为研究组,另选取同期接收的90例健康体验人员为对照组,运用免疫荧光分析法对两组人员的血清PCT水平进行检测,采用日立7600-120全自动生化分析仪对两组人员的血清LAC水平进行检测,然后对两组人员的血清PCT、LAC水平、研究组存活和病死患者的血清PCT、LAC水平进行统计分析.结果 研究组患者治疗后的血清PCT、LAC水平均显著低于治疗前(P<0.05);治疗前研究组患者的血清PCT、LAC水平均显著高于对照组(P<0.05),治疗后两组患者的血清PCT、LAC水平之间的差异未见统计学意义(P>0.05);90例患者中,存活75例,病死15例,病死率为16.7％,其中病死患者的血清PCT、LAC水平均显著高于存活患者(P<0.05).结论 血清PCT、LAC水平检测在糖尿病酮症酸中毒合并院内获得性肺炎患者疗效评估中具有较高的应用价值.