幽门螺杆菌根除疗法治疗慢性特发性血小板减少性紫癜的对照研究

摘要

目的 观察幽门螺杆菌(Hp)根除疗法治疗Hp阳性的慢性特发性血小板减少性紫癜(ITP)的疗效.方法 59例Hp阳性的慢性ITP患者,按随机数字表法分为抗Hp组(治疗组,30例)和安慰剂组(对照组,29例),随访3个月后,比较两组的疗效.结果 治疗组有效率(63.3%,19/30)明显高于对照组(27.6%,8/29)(x2=7.59,P＜0.05),治疗组血小板计数升高值[(33.5±21.6)×109/L]明显高于对照组[(12.6±19.5)×109/L](t=5.52,P＜0.05).结论 Hp根除疗法可升高轻中度Hp阳性慢性ITP患者的血小板计数.%Objective To assess the effect of anti- Helicobacter pylori (Hp) treatment on patients with chronic idiopathic thrombocytopenic purpura (cITP). Methods Fifty-nine patients with cITP and positive-Hp were divided into two groups by random digits table:Hp eradication group (30 cases,given a standard anti-Hp treatment) and placebo controlled group (29 cases,received a placebo). The platelet response of two groups was compared after three months' follow-up. Result The platelet response in Hp eradication group (63.3%, 19/30) was significantly higher than that in placebo controlled group (27.6%,8/29 )(χ2 = 7.59, P ＜ 0.05 ), and the increasing level of platelet count in Hp eradication group [ (33.5 ± 21.6)× 109/L] was higher than that in placebo controlled group [(12.6 ± 19.5) × 109/L] (t = 5.52,P ＜0.05).Conclusion Hp eradication treatment can promote the platelet recovery in mild and moderate cITP patients with positive-Hp.