Use of ribavirin and interferon alpha to prepare pharmaceutical compositions for treating antiviral treatment naive patient having chronic hepatitis C genotype I infection and a viral load of greater than 2 million copies per ml of HCV-RNA as measured by quantitative PCR to eradicate detectable HCV-RNA involving a combination therapy using a therapeutically effective amount of ribavirin and a therapeutically effective amount of interferon-alpha for a total time period of 40 to 50 weeks are disclosed.
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