目的：探讨突发性耳聋患者高刺激听性脑干反应的特点及临床价值。方法对2014年1月至12月就诊于我院的43例（45耳）16～45岁青中年无眩晕、心脑血管疾病病史的突聋患者（病例组）及同龄听力正常人20例40耳（对照组）分别进行纯音测听和高（51.1次／秒）、低（11.1次／秒）刺激率听性脑干反应（auditory brainstem response，ABR）检测，以两种刺激率的ABRⅠ-Ⅴ波间期差值（interpeak latency，△IPL）＞0.28为异常。比较突聋患者中ABR结果异常者（A组）与ABR结果正常者（B组）间的治疗有效率。采用SPSS13.0软件，以χ2检验比较两组间的差异。结果病例组患侧高刺激ABR引出率为75.56%（34例），其中异常率为79%（27例）；对照组高刺激ABR引出率为100%，异常率为5%（2例），两组间高刺激ABR异常率差异有统计学意义（χ2＝42.124，P＜0.01）。A组与B组突聋患者的平均纯音听阈结果无明显差异；病例组中A组治疗有效率为40.74%（11例），B组的有效率为83.33%（15例），两组间比较差异有统计学意义（χ2＝6.613，P=0.005）。结论突聋患者高刺激ABRⅠ-Ⅴ波间期差异常率明显增加，且高刺激ABR结果异常提示预后较差。%Objective To report characteristics of high-frequency stimulation Auditory Brainstem Responses in pa-tients with idiopathic sudden sensorineural hearing loss (ISSHL). Methods Forty three patients (45 ears) aged 16-45 years with ISSHL who were treated in Guangzhou Otolaryngology Head and Neck Surgery Hospital between January 2014 and December 2014 were included in the study group, while 20 normal volunteers (40 ears) were recruited as the control group. Subjects had no history of vertigo or cerebrocardiovascular diseases, and received pure tone audiometry (PTA) tests. Audito-ry brainstem responses (ABRs) were tested using clicks at a rate of 51.1/s or 11.1/s. A difference in I-V interpeak latency be-tween high and low frequency stimulation ABRs (△IPL) of 0.28 ms or greater was categorized as“abnormal”. Reponses to treatment in patients with abnormal △IPL and in those with normal △IPL were compared. Results There was no significant difference in PTA between patients with abnormal △IPL and those with normal △IPL. High frequency stimulation ABRs were recorded in 34 patients (75.56%) and in all normal subjects (100%). Among ISSHL patients with abnormal △IPL, 11 (40.74%) showed improvement, compared to 15 (83.33%) of those with normal △IPL (P=0.005). Conclusion The rate of ab-normal △IPL from low and high frequency stimulation ABRs is increased in ISSHL patients. ISSHL patients with abnormal △IPL have poorer hearing prognoses compared with those with normal △IPL.
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