皮肤真菌病新型局部给药系统研究进展

摘要

Cutaneous mycosis is a common and frequent kind of dermatosis, seriously affecting the quality of patients' life.With advantages of easy application and good patient compliance, topical drug delivery systems are the first choice to treat cutaneous mycosis, which act on the target sites directly.New drug delivery systems (NDDS) such as liposomes, ethosomes, microemulsions and lipid nanoparticle could increase the drug permeation,reduce the drug transdermal transport and result in accumulation of drug within skin.As a result, the NDDS could enhance the therapeutic effect, shorten therapy periods and reduce side effects.All these show a great application prospects in the topical treatment of cutaneous mycosis.According to related publications, recent advances in novel topical drug delivery systems for cutaneous mycosis were reviewed.%皮肤真菌病是易发病、易传染、易复发的疾病,严重影响患者生活质量.局部给药制剂直接作用于病变部位,使用方便,患者顺应性好,是皮肤真菌病临床治疗的首选.以脂质体、醇质体、微乳和脂质纳米粒等为代表的新型给药系统,可以提高药物的渗透性,减小药物透过,使其在皮肤局部蓄积,从而能够增强疗效、缩短疗程和减少不良反应,使皮肤真菌病的局部治疗更具有应用前景.本文综述了近年来国内外皮肤真菌病新型局部给药系统的研究进展.