免疫细胞在调节脂肪组织慢性炎症中的功能

摘要

Inflammation is part of the body′s response to invading pathogens and a crucial process in the maintenance of homeostasis .A variety of regulatory mechanisms are involved in inflammation process to limit the damage caused by excessive immune response to the host .Previous studies have shown that insu-lin resistance , type 2 diabetes , liver fibrosis and cardiovascular disease are caused by persistent chronic in-flammation in metabolic tissue (brain, fat, liver, pancreas, etc), especially in adipose tissue.However, the underlying mechanisms of these conditions have not been fully understood .The role of innate and adap-tive immune cells in these diseases attracts increasing attention .In this review, we will focus on the role of various immune cells in adipose tissue in the initiation and development of inflammation and discuss the effi -cacy of potential anti-inflammatory therapies based on their mechanisms .%炎症是机体抵抗入侵的病原体用来维持体内平衡必不可少的一个过程,这个过程受到多种机制的调控以限制对宿主过度免疫应答带来的损伤.之前的研究表明,胰岛素抵抗2型糖尿病、肝纤维化和心血管疾病,都是由于代谢组织(大脑、脂肪、肝脏、胰腺等),尤其是脂肪组织持续的的慢性炎症所导致.然而,它们潜在的机制仍未完全解释清楚.在这些疾病中,固有免疫与适应性免疫细胞的作用越来越受到人们的关注.在这篇综述里,我们将重点阐明脂肪组织中各种免疫细胞在炎症的起始和发展中所起的作用,并从不同的机制来讨论潜在的抗炎治疗方法.