全胃及远端胃切除胃癌根治术对患者生活质量及免疫指标的影响

摘要

目的：探讨根治性全胃切除与根治性远端胃切除胃癌根治术这两种术式对患者生活质量及免疫指标的影响情况。方法：选取2005年6月~2010年6月来我院因胃癌行根治性手术后生存期超过2年的89例患者的临床资料，其中根治性全胃切除者51例，根治性远端胃切除者38例，比较两组患者术后半年、1年、2年生活质量调查问卷评分及CD4、CD8淋巴细胞数量、CD4/CD8比例、IgA、IgG、IgM等相关免疫指标。结果：远端胃切除术后的患者其生活质量评分及免疫状况均明显优于全胃切除的患者，具有统计学意义(P<0.05)。结论：根治性远端胃切除与根治性全胃切除相比，其对患者生活质量及免疫指标影响较小，应根据手术方式的不同，采取针对性的措施，提高患者的生活质量。%Objective:To investigate the influence of radical total gastrectomy and radical distal gastrectomy on patients' quality of life and immune index. Methods:The clinical data of 89 cases of gastric cancer received radical gastrectomy during June 2005 to June 2010 in our hospital and survived more than two years were collected.51 cases received radical total and 38 cases received radical distal gastrectomy. The quality of life questionnaire score and CD4,CD8 lymphocyte count,CD4/CD8 ratio,IgA,IgG, IgM,and other related immune index after six months, one year and two years were compared between the two groups. Results:The immune status and quality of life scores of patients received distal gastrectomy were significantly better than those of patients received total gastrectomy. The differences were statistical significance (P<0.05). Conclusion:Compared with radical total gastrectomy,radical distal gastrectomy would have less influence on the quality of life and immune statues of patients with gastric cancer. Targeted measures should be taken to improve the patient's quality of life based on different surgical methods.