血清IL-6与PCT在新生儿肺炎早期诊断中的检测意义

摘要

目的:探析新生儿肺炎(NP)患儿的早期诊治中血清白细胞介素6(IL-6)与降钙素原(PCT)的临床检测意义.方法:分析82例NP患儿的临床资料,列为观察组(A组),按细菌感染情况将A组分成A1组(细菌感染性肺炎,45例)和A2组(非细菌感染性肺炎,37例).另选同期体检的44例正常体检新生儿为对照组(B组).比较各组的基线资料及治疗前后血清IL-6与PCT的表达水平.分析血清IL-6与PCT对NP患儿的诊断价值.结果:A组与B组儿童的基线资料无显著差异性(P＞0.05).A1组的血清IL-6与PCT水平显著较A2组、B组高(P＜0.01).A1患儿治疗前的血清IL-6与PCT水平显著较治疗后高(P＜0.01).血清IL-6与PCT对NP患儿的诊断价值各不相同.结论:血清IL-6与PCT在NP患儿的早期诊断中具有重要的临床检测意义.%Objective:To investigate the clinical significance of serum interleukin 6 (IL-6) and procalcitonin (PCT) in the early diagnosis and treatment of neonatal pneumonia(NP).Methods:The clinical data of 82 cases of NP,as the observation group (group A),according to the situation of bacterial infection of A were divided into A1 group (bacterial pneumonia,45 cases) and group A2 (non bacterial pneunonia,37 cases).44 normal neonates were selected as control group (B group).The baseline data and the levels of serum IL-6 and PCT were compared before and after treatment.Diagnostic value of serum IL-6 and PCT in children with NP.Results:There was no significant difference in baseline data between the A group and the B group (P ＞ 0.05).The serum IL-6 and PCT levels in group A1 were significantly higher than those in A2 group and B group (P ＜ 0.01).The levels of serum IL-6 and PCT in children with A1 were significantly higher than those before treatment (P ＜ 0.01).The diagnostic value of serum IL-6 and PCT in children with NP is different.Conclusion:Serum IL-6 and PCT have important clinical significance in early diagnosis of NP.