奥曲肽防治结直肠癌根治术后放疗致腹泻的效果

摘要

Objective To prevent and treat the diarrhea caused by radiotherapy following the radical resection of colorectal cancer with the use of octreotide.Methods A total of 108 patients with colorectal cancer admitted from March 2013 to March 2016 were selected.All patients were treated with radical resection and radiotherapy.The patients were randomly divided into octreotide group and routine group,54 cases in each group.The routine group was treated with routine preventive measures,while the octreotide group was treated with routine preventive measures and octreotide.The incidence and therapeutic effect of diarrhea,and the incidence of adverse reactions were compared between the two groups.Results The incidence of diarrhea in octreotide group was significantly lower than that in routine group [27.8％ (15/54) vs 48.1％ (26/54)] (P＜0.05).The total effective rate of the treatment for diarrhea in octreotide group was significantly higher than that in routine group [93.7％ (14/15) vs 65.4％ (17/26)] (P＜0.05).No difference in the incidence of adverse reactions was found between the two groups (P＞0.05).Conclusion Octreotide can effectively prevent and control radiotherapy-associated diarrhea,and is safe in clinical use,which helps the smooth implementation of radiotherapy following the radical resection of colorectal cancer.%目的:研究奥曲肽防治结直肠癌根治术后放疗致腹泻的效果.方法:选取我院2013年3月至2016年3月108例结直肠癌患者为研究对象,所有患者均接受根治性手术+放疗.将纳入患者抽签随机分为奥曲肽组与常规组,每组54例.常规组给予常规防治措施,奥曲肽细在常规防治基础上加用奥曲肽,比较两组腹泻发生率、腹泻治疗效果以及不良反应发生率.结果:奥曲肽细腹泻发生率为27.8％(15/54),显著低于常规组的48.1％(26/54) (P＜0.05);奥曲肽组腹泻治疗总有效率为93.7％(14/15),显著高于常规组的65.4％(17/26)(P＜0.05);两组不良反应率比较差异无统计学意义(P＞0.05).结论:奥曲肽可以有效预防和控制放疗相关性腹泻,临床使用安全性高,有利于结直肠癌根治术后放疗的顺利进行.