目的 探讨健康成人经不同时长(24/36 h)睡眠剥夺(sleep deprivation,SD)后静息态脑局部一致性的变化.材料与方法 28名健康受试采用重复测量自身对照试验设计,分别于正常睡眠状态、24 h睡眠剥夺后及36 h睡眠剥夺后行静息态功能磁共振成像扫描.采用局部一致性(regional homogeneity,ReHo)分析方法,再以SPM8软件进行单因素方差分析,设对比差异有统计学意义(FWE校正,P<0.001),体素范围(K值)>20.结果 SD后较正常睡眠对比,ReHo显著升高的脑区为:右侧梭状回、额中回、颞中回及左侧丘脑和岛叶,以右侧额中回最为显著;显著降低的脑区为:右侧楔前叶、额上回、缘上回及左侧额中回、中央后回、角回,其中以左侧中央后回最为显著;随着剥夺时间的延长,较24 h失眠剥夺组,36 h睡眠剥夺后全脑ReHo显著升高的脑区为:双侧丘脑、右侧颞叶、海马旁回及左侧额中回;ReHo显著降低的脑区为:双侧额中回、中央后回、左侧楔前叶、枕中回及右侧额上回和补充运动中枢.结论 SD所引起的一系列行为学变化是通过"调节"相关脑功能区功能的活跃程度来实现的,主要集中在双侧额叶、丘脑、左侧颞叶及相关运动功能区,并且调节的强度与睡眠剥夺时长有密切关系,随着睡眠剥夺时间延长,相应脑功能区的变化越显著.%Objective: To investigate the changes of sleep deprivation (SD) with different times on human brain regional homogeneity (ReHo). Materials and Methods: Twenty-eight healthy individuals participated in this study. Resting-state fMRI scans were collected under rest wakefulness and 24 and 36 hours SD. The ReHo approach was employed to analyze the imaging data, and SPM8 was used to perform one-way ANOVA, with a P value<0.001 (corrected FWE) and cluster size (k value)>20 voxels considerate statistic significant. Results: Compared with rest wakefulness, mainly SD induced enhanced brain ReHo in the right fusiform, the frontal, temporal lobe and the left thalamus; decreased ReHo in the right precuneus, supramarginal and the left frontal middle lobe, postcentral. With SD times went on, enhanced brain ReHo were found in precuneus, angular and frontal sup medial; and decreased ReHo were found in the precentral gyrus, temporal lobe and medial frontal gyrus. Conclusion:SD caused abnormal changes in whole brain network changes by connection of multiple brain regions, especially the brain regions which are mainly in the frontal lobe, temporal lobe and thalamus. And the SD times can reflect the changes of ReHo in functional regions.
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