放疗技术与放射性肺损伤：高剂量小体积还是低剂量大体积？

摘要

放射治疗是肺癌的主要治疗手段之一，目前使用的主流技术是三维适形放疗（three-dimensional conformal radiation therapy,3D-CRT）和调强适形放疗（intensity modulated radiation therapy, IMRT），两者各具特点。本文综述近年来两种放疗技术治疗肺癌的文献，重点讨论放射剂量在肺内的分布与放射性肺炎的关系，即高剂量分布在较小的肺体积与低剂量分布在较大的肺体积，两者哪种更易引发放射性肺炎（radiation pneumonitis, RP）。%Radiotherapy is one of the main treatment for patients with lung cancer. hTree-dimensional conformal radiation therapy (3D-CRT) and intensity modulated radiation therapy (IMRT) are widely used to deliver radiation. Here, we focus on the correlations between dose distribution in lung and radiation pneumonitis according to the analysis about radio-therapy for lung cancer: A lot to a little or a little to a lot, which is the main cause of radiation pneumonitis?