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LOW-VOLUME, CABLE-stable, low-dose, dose-free ROTAVIRUS VACCINE, VACCINE FORMULATION AND METHOD FOR GENERATING IMMUNOLOGICAL RESPONSE
LOW-VOLUME, CABLE-stable, low-dose, dose-free ROTAVIRUS VACCINE, VACCINE FORMULATION AND METHOD FOR GENERATING IMMUNOLOGICAL RESPONSE
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机译:小体积,稳定的电缆,低剂量,无剂量的轮状病毒疫苗,疫苗制剂和产生免疫反应的方法
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摘要
It is a low-dose, acid-stable, buffer-free rotavirus vaccine. The vaccine is available in a dose volume of less than 1 ml per dose for oral administration and without any buffer. The vaccine also does not require pre or post administration of any antacid at the time of oral administration of the vaccine to the individual to neutralize stomach acid. The vaccine exemplifies nominal drop in vaccine titer to ph 2 to 4 over a 30 minute time interval. The vaccine is stable at -20 ° C for at least 60 months.
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