HMGB1与肝损伤相关研究进展

摘要

High mobility protein B1 (HMGB1) is a member of high mobility group (HMG),which exist in eukaryotic cells.HMGB1 is not only a kind of nuclear protein,but also a pro-inflammatory factor.The increasing level of HMGB1 in the body often suggests cell destruction or inflammatory reaction.Various causes of liver injury can lead to the release of HMGB1,and the content of HMGB1 not only help diagnose liver injury,but also predict the prognosis of liver injury.To study the mechanism of HMGB1 in liver injury can help to get a certain guiding significance for therapeutic targets.This article will focus on the mechanisms of HMGB1 involved in liver injury,the relationship between HMGB1 and liver injury,the prognosis and treatment targets of liver injury,and future application prospects.%高迁移率蛋白B1(high mobility group protein box 1,HMGB1)为高迁移率族(high mobility group,HMG)成员之一,存在于真核生物细胞内.HMGB1不仅是一种核内蛋白,也是一种促炎因子,体内HMGB1升高往往提示细胞破坏或炎症反应.各种原因所致的肝损伤可导致HMGB1释放,HMGB1含量不仅对肝损伤的诊断有提示作用,对其预后也有一定的预测作用.研究HMGB1对肝损伤的作用机制,对治疗靶点有一定的指导意义.本文对HMGB1参与肝损伤的作用机制、与肝损伤的关系、预后分析、治疗靶点研究及未来应用前景予以综述.