阴道微生态失调与不孕症相关性的系统评价

摘要

目的 系统评价阴道微生态失调与不孕症的相关性.方法 采用Cochrane系统评价方法,检索MEDLINE、EMBASE和SinoMed数据库,检索时限为建库至2017年10月,并手工检索相关参考文献,纳入研究阴道微生态失调与不孕症相关性的队列研究、病例对照研究和横断面研究.应用RevMan 5.3软件进行Meta分析.结果 检索到文献1724篇,纳入9个横断面研究,不孕症患者1702例,对照1665例.Meta分析结果提示,不孕症患者的阴道微生态失调发生率高于对照组[OR=3.15,95%CI(1.57,6.32),P=0.001].结论 尽管现有证据表明阴道微生态失调与不孕症的发生具有相关性,但需进一步开展高质量病例对照研究或队列研究以验证此结论.(中华检验医学杂志,2018,41:281-286)%Objective To evaluate the association of vaginal dysbiosis and infertility.Methods Cohort studies, case-control studies and cross-sectional studies were searched in electronic databases, including MEDLINE,EMBASE and SinoMed(from inception to October 2017);in addition, the reference lists of included studies and similar reviews were handsearched.These studies investigating the correlation between vaginal dysbiosis and infertility were included.The Meta-Analysis was performed by RevMan 5.3 software.Results 1 724 records were retrieved by the search; from those,9 cross-sectional studies were included,comprising 3 367 participants(1 702 in infertility group and 1 665 in control group).The likelihood of vaginal dysbiosis in infertility group is higher than that of control group[OR=3.15,95% CI (1.57,6.32), P=0.001].Conclusions The available evidence suggests that vaginal dysbiosis was associated with the incidence of infertility.However, further case-control studies or cohort studies are required to confirm or refute these findings.(Chin J Lab Med,2018,41:281-286)