PRL水平变化与内分泌失调性不孕症相关性研究

摘要

Objectives:To explore the correlation between the change in prolactin (PRL) level and endocrine dysfunctional infertility.Methods:120 infertile women diagnosed and treated in the hospital (observation group) and 120 normal women of childbearing age during the same period (control group) were selected.The women in observation group were divided into menstrual disorder group (82 women) and normal menstruation group (32 women) according to the existence of menstrual disorder or not.The levels of PRL,follicle-stimulating hormone (FSH),luteinizing hormone (LH),estradiol and testosterone in different groups were compared.Results:The levels of PRL,FSH and LH in observation group were significantly higher than those in control group,with statistical significance (P ＜ 0.05).The levels of estradiol and testosterone in observation group were significantly lower than those in control group(P ＜0.05) with statistical significance.The levels of PRL,FSH and LH in menstrual disorder group were significantly higher than those in normal menstruation group (P ＜ 0.05) with statistical significance.There was no statistically significant difference in the levels of estradiol and testosterone between menstrual disorder group and normal menstruation group (P ＞ 0.05).There was a significantly positive correlation between PRL level and LH level (r =0.528,P =0.000).There was a significantly positive correlation between PRL level and FSH level (r =0.529,P =0.000).There was a significantly negative correlation between prolactin level and estradiol level (r =-0.548,P =0.000).There was no correlation between prolactin level and testosterone level (r =0.052,P =0.079).Conclusion:The PRL level in patients with endocrine dysfunctional infertility is significantly higher than that in normal women of childbearing age,so the detection of PRL level is of important significance for the diagnosis of infertility.Besides,PRL level is correlated with FSH,LH and estradiol levels.%目的:探讨泌乳素(PRL)水平变化与内分泌失调性不孕症的相关性.方法:选取我院120例不孕症患者作为观察组,其中根据月经周期紊乱与否分为月经紊乱组(82例)和月经正常组(38例),另选取同期健康体检者120例作为对照组,测定观察组和对照组的PRL、雌二醇(E2)、卵泡刺激素(FSH)、睾酮(T)和促黄体激素(LH)水平.结果:观察组患者的PRL、FSH及LH水平明显高于对照组,差异比较均有统计学意义(P＜0.05);观察组的T和E2水平明显低于对照组,差异比较均有统计学意义(P＜0.05);月经紊乱组的PRL、FSH及LH明显高于月经正常组,差异比较均有统计学意义(P＜0.05),但T及E2与月经正常组相比无显著性差异(P＞0.05);观察组患者的PRL与LH呈正相关(r=0.528,P=0.000),与FSH存在明显正相关(r =0.529,P=0.000),与E2负相关(r=-0.548,P=0.000),与T无相关性(r =0.052,P=0.081).结论:内分泌失调性不孕症患者的PRL水平明显高于正常人群,其与E2、FSH、LH存在明显相关性,PRL的水平检测对内分泌失调性不孕症的临床诊断具有重要意义.