Objective To investigate the effects of trhnetazidine on cardiac function in rats with ischemic heart failure .Methods We established ischemic heart failure rats by the left coronary artery ligation .30 rats after operation were separated randomized into 3 groups .Trimetazidine was given intervention within 24 hours after surgery in one group (TI group ) and after 4 weeks in another group (TF group) .The 3rd group was heart failure control group (F group).After 8 weeks we observed the cardiac index ,hemodynamic changes of each groups compared with the sham group (S group ) ,and SOD ,MDA changes in each groups .Results Trimetazidine was significantly improved cardiac function compared to F group .and significantly aggrandized the activity of SOD ,reduced content of MDA ( P＜0.01 ) .The improvement was more significant in TI group .Conelttsion Trimetazidine can improve heart function in rats with ischemic heart failure ,and the effect is more obvious in early stage.%目的 探讨曲美他嗪对缺血性心力衰竭大鼠心脏功能的影响,其作用与给药时间的关系.方法 采用结扎左冠状动脉的方法,建立缺血性心力衰竭大鼠模型,对两组模型大鼠分别于术后24小时内及术后4周,给予曲美他嗪干预,与术后8周观察心脏指数、血流动力学改变,与假手术组及心衰对照组比较,同时比较SOD、MDA的改变.结果 药物干预治疗的大鼠在心脏指数、血流动力学方面相比心衰组均有明显改善,并可以显著升高SOD活性,降低MDA水平,术后24小时应用曲美他嗪组改善更明显.结论 曲美他嗪可以明显改善缺血性心力衰竭大鼠心脏功能,且早期应用效果更加明显.
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