多发性骨髓瘤患者血清lncRNA HOTAIR表达量与血清β2微球蛋白及预后的相关性

摘要

Objective To analyze the correlation between serum long chain non encoding RNA (lncRNA)HOTAIR expression level, serum beta2-microglobulin(β2 -MG)and prognosis in patients with multiple myeloma(MM).Methods 100cases of MM patients were selected as the case group and divided into the efficient group (74cases)and the un-efficient group (26cases)according to the therapeutic effects of chemotherapy.50healthy volunteers were selected as the control group.The serum lncRNA HOTAIR andβ2-MG levels of the objects in each group were detected and com-pared.The patients in the case group were followed up, the overall survival (OS)and the progression free survival (PFS)of the patients were observed and compared.Results The serum lncRNA HOTAIR andβ2-MG levels of the pa-tients in the case group were significantly higher than those in the control group, the serum lncRNA HOTAIR andβ2-MG levels of the patients in the unefficient group were significantly higher than those in the efficient group, the differ-ences were statistically significant(t=18.445, 45.023, 16.212, 22.679, P＜0.05);The serum lncRNA HOTAIR level was correlated with theβ2-MG level of the patients in the case group, the efficient group or the unefficient group(r=0.880, 0.695, 0.893, P ＜0.05);OS, PFS of the patients with high level of serum lncRNA HOTAIR orβ2-MG level were higher in patients with low level of serum lncRNA HOTAIR orβ2-MG level, the differences were statistically sig-nificant(χ2=39.435, 37.371, 38.054, 34.696, P＜0.05).Conclusion MM patients show elevated level of serum ln- cRNA HOTAIR and the level has a close correlation withβ2-MG level.Meanwhile, the levels of two serum markers are correlated with the therapeutic effects of chemotherapeutic agents and the survival of the patients, can be used as assis-tant indexes to evaluate the therapeutic effects and the prognosis.%目的 分析多发性骨髓瘤(MM)患者血清长链非编码RNA(lncRNA)HOTAIR表达量与血清β2 微球蛋白(β2-MG)及预后的相关性.方法 选取100例 MM患者作为病例组, 根据化疗治疗效果将其分为有效组(74例)和无效组(26例),选取50例健康志愿者作为对照组.对各组研究对象的血清lncRNA HOTAIR水平、β2-MG水平进行检测和比较;对病例组患者进 行随访,对患者的总生存期(OS)和无疾病进展生存期(PFS)进行观察和比较.结果 病例组患者的血清lncRNA HOTAIR水平和β2-MG水平均显著高于对照组,无效组的血清lncRNA HOTAIR 水平和β2-MG水平均显著高于有效组,差异均有统计学意义(t=18.445、45.023、16.212、22.679,P＜0.05);病例组患者及有效组、无效组患者的血清lncRNA HOTAIR水平均与β2 -MG水平具有相关性(r=0.880、0.695、0.893,P＜0.05);血清lncRNA HOTAIR水平和β2-MG水平较高患者的OS、PFS均显著低于血清lncRNA HOTAIR和β2-MG水平较低的患者,差异 均有统计学意义(χ2=39.435、37.371、38.054、34.696,P＜0.05).结论 MM患者表现为血清lncRNA HOTAIR水平的升高,其水平与β2-MG水平具有密切的相关性,而且这两种血清 标志物水平与化疗药物的治疗效果和生存期有关,可作为评价治疗效果和预测预后的辅助指标.