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Analysis of the secondary structure of blood serum proteins from patients with multiple myeloma

机译:多发性骨髓瘤患者血清血清蛋白二次结构分析

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Infrared spectroscopy of biomolecules is one of the few methods, which combine a relatively simple measurements and a possibility of highly informative structural analysis. The most high-demand field of such investigations is the identification of various pathologies accompanied by changes in the biomolecular structure. In this study the comparative analysis of the secondary structure of blood serum proteins from patients with multiple myeloma and healthy donors was performed using infrared spectroscopy. There is a tendency for reduce the proportion of α-helices in the secondary structure of blood serum proteins in patients with multiple myeloma compared to healthy donors. Thus, infrared spectroscopy reveals difference in the secondary structure of blood serum proteins in patients with multiple myeloma and healthy donors.
机译:生物分子的红外光谱是少数方法之一,它结合了相对简单的测量和高度信息性结构分析的可能性。 这些研究的最高需求领域是鉴定各种病理学伴随着生物分子结构的变化。 在这项研究中,使用红外光谱进行多种骨髓瘤和健康供体患者血清血清蛋白二次结构的比较分析。 与健康供体相比,患有多个骨髓瘤患者的血清血清蛋白二次结构中的α-螺旋的比例趋势。 因此,红外光谱揭示了多种骨髓瘤和健康供体患者血清血清蛋白二次结构的差异。

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