Comparison of Serum Beta 2-Microglobulin and 24 hour Urinary Creatinine Clearance as a Prognostic Factor in Multiple Myeloma

摘要

A new staging system for multiple myeloma (MM) has utilized serum concentrations of beta 2-microglobulin (Sβ₂M) and albumin as important prognostic factors for survival. Since Sβ₂M is an indicator of glomerular filtration rate, we compared the prognostic values of Sβ₂M and 24-hr urinary creatinine clearance (Ccr) in patients with MM. We retrospectively reviewed the records of 170 MM patients from January 1996 to November 2003 whose 24-hr urinary Ccr was available at the time of diagnosis. We found that pretreatment Sβ₂M was inversely related to Ccr (Spearman's correlation coefficient=-0.787). In univariate analysis, the hazard ratio (HR) of death was 1.043 ( p 2M and 0.985 ( p 2M (HR 1.030, p =0.010) and Ccr (HR 0.993, p =0.059) were significant prognostic factors in patients' survival. In conclusion, 24-hr urinary Ccr may be utilized for staging of patients with MM.