目的:通过对451例乙型肝炎相关慢加急性肝衰竭患者临床治疗方案的总结分析,探讨中西医结合治疗方案的疗效以及对近期预后的影响.方法:收集2007年1月- 2010年12月在我院住院治疗的乙型肝炎相关慢加急性肝衰竭患者的临床资料,建立EpiData数据库.根据患者的不同治疗方案分为中西医结合治疗组和西药治疗组,观察治疗第4周和第8周不同治疗方案对患者生化指标、生存率、并发症发生率及总有效率的影响.结果:中西医结合组在降低总胆红素( TBil)及升高凝血酶原活动度(PTA)方面与西药组比较差异有显著性意义(P＜0.05),且中西医结合组的并发症发生率降低、生存率提高(P＜0.05),两组总有效率比较差异有显著性意义(P＜0.05).结论:中西医结合治疗慢加急性肝衰竭具有良好的效果,能更好地消退患者黄疸、改善PTA,减少并发症的发生,提高患者的生存率.%Objective: Analyzing of clinical treatment programs of 451 patients with HBV-ACLF and exploring the effect of integrated traditional Chinese and western medicine therapy to short-term prognosis. Methods: Clinical data of 451 hospitalized patients with HBV-ACLF from Jan. 2007 to Sept 2010 were collected to establish a clinical database. The combination therapy group was given cooling blood and detoxification method combining western medicine treatment, and the western medicine treatment group was only treated with western medicine, observing biochemical parameters, survival rate, complication rate and total efficiency after treating4 weeks and 8 weeks. Results; For the combination therapy group, reduced serum total bilirubin (Tbil) and elevated prothrombin time activity (PTA) were statistically significant (P <0.05) , with low incidence of complications and high survival rate (P <0.05) . The total effective rate were significantly different Conclusion: Integrated traditional and west-em medicine treatment can achieve good therapeutic effects for HBV-ACLF patients. It can remarkably dissipate jaundice, improve prothrombin time activity, reduce complications, and improve rate of survival
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