ObjectiveTo study the anti-inflammatory effect of traditional Chinese medicine (TCM) Changweishu on sepsis patients with gastrointestinal dysfunction and its protective effect on intestinal mechanical barrier.Methods A prospective research method was conducted. Fifty sepsis patients with gastrointestinal dysfunction admitted into Department of Emergency Intensive Care Unit (EICU) of Hebei Provincial TCM Hospital from October 2013 to June 2015 were enrolled, and they were divided into a conventional treatment of western medicine control group and a TCM Changweishu group according to the random number table method, 25 cases in each group. The conventional western medicine treatment was given to both groups, and in TCM Changweishu group, additionally Changweishu 1 dose per day, a mixture of following ingredients constituting one dose without decoction, was applied, including: rhubarb 9 g, dandelion 20 g, green tangerine peel 15 g, angelica sinensis radix 15 g, red and white peony each 12 g, rhizome ligusticum 9 g, agrimony 20 g, coptidis rhizoma 6 g, rhizoma pinelliae 6 g, fructus trichosanthis 15 g, garden burnet root 20 g, poria 20 g, and taken once 1/2 dose in the morning and once 1/2 dose in the evening by oral or nasal feeding. After treatment for 7 days, the level changes of inflammatory factors of tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6), high mobility group protein B1 (HMGB1) and gastrointestinal dysfunction indexes of diamine oxidase (DAO), D-lactic acid in the two groups were observed.Results After treatment, the levels of TNF-α, IL-6, HMGB-1, DAO, D-lactic acid in the two groups were significantly lower than those before treatment [the western medicine control group: TNF-α (A value) 10.89±1.65 vs. 50.30± 1.58, IL-6 (A value) 7.35±1.85 vs. 12.66 ± 1.43, HMGB1 (A value) 5.28 ±1.64 vs. 6.23±0.95, DAO (A value) 5.87±0.59 vs. 6.67±0.49, D-lactic acid (A value) was 2.63±0.17 vs. 4.58±0.16; TCM changweishu group: TNF -α (A value) 5.38±1.19 vs. 51.23±2.34, IL-6 (A value) 5.54±1.26 vs. 13.24±1.78, HMGB1 (A value) 3.69±1.09 vs. 6.14±1.42, DAO (A value) was 3.39± 0.40 vs. 6.70±0.34, D-lactic acid (A value) 1.95±0.13 vs. 4.63±0.11, allP < 0.05]. After treatment, the degrees of decline in indexes of TCM Changweishu group were more obvious than those in western medicine control group [TNF-α(A value) 5.38±1.19 vs. 10.89±1.65, IL-6 (A value) 5.54±1.26 vs. 7.35±1.85, HMGB1 (A value) 3.69 ±1.09 vs.5.28±1.64, DAO (A value) 3.93±0.40 vs. 5.87±0.59, D-lactic acid (A value) 1.95±0.13 vs. 2.63±0.17, allP <0.05].Conclusions TCM Changweishu has protective effect on sepsis patients with gastrointestinal dysfunction, and its mechanisms are the amelioration of damage in intestinal tract mechanical barrier, decrease of permeability of intestinal mucosa and inhibition of levels of inflammatory factors.%目的：研究中药肠胃舒对脓毒症胃肠功能障碍患者的抗炎效果及肠道机械屏障保护作用。方法采用前瞻性研究方法，选择2013年10月至2015年6月河北省中医院急诊重症加强治疗病房（EICU）收治的50例脓毒症胃肠功能障碍患者，按随机数字表法将患者分为西药对照组和中药肠胃舒组，每组25例。两组均给予西药常规治疗，中药肠胃舒组在西药常规治疗基础上给予肠胃舒（川军9 g，蒲公英20 g，青皮15 g，当归15 g，赤白芍药各12 g，川芎9 g，仙鹤草20 g，川连6 g，清半夏6 g，瓜蒌15 g，地榆20 g，茯苓20 g）每日1剂，分早晚2次口服或鼻饲。治疗7 d后，观察两组患者炎性因子肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、高迁移率族蛋白B1（HMGB1）及胃肠功能障碍指标二胺氧化酶（DAO）、D-乳酸的变化。结果西药对照组和中药肠胃舒组患者治疗后TNF-α、IL-6、HMGB-1、DAO、D-乳酸水平均较治疗前明显降低〔西药对照组：TNF-α（A值）为10.89±1.65比50.30±1.58，IL-6（A值）为7.35±1.85比12.66±1.43，HMGB1（A值）为5.28±1.64比6.23±0.95，DAO（A值）为5.87±0.59比6.67±0.49，D-乳酸（A值）为2.63±0.17比4.58±0.16；中药肠胃舒组：TNF-α（A值）为5.38±1.19比51.23±2.34，IL-6（A值）为5.54±1.26比13.24±1.78，HMGB1（A值）为3.69±1.09比6.14±1.42，DAO（A值）为3.39±0.40比6.70±0.34，D-乳酸（A值）为1.95±0.13比4.63±0.11，均P＜0.05〕，中药肠胃舒组治疗后的下降程度较西药对照组更加明显〔TNF-α（A值）：5.38±1.19比10.89±1.65，IL-6（A值）：5.54±1.26比7.35±1.85，HMGB1（A值）：3.69±1.09比5.28±1.64，DAO（A值）：3.93±0.40比5.87±0.59，D-乳酸（A值）：1.95±0.13比2.63±0.17，均P＜0.05〕。结论中药肠胃舒可保护脓毒症胃肠功能障碍患者的肠道机械屏障，降低肠道黏膜通透性，抑制炎性因子水平。
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