Objective To study the early diagnostic value of procalcitonin(PCT),high-sensitivity C-reactive pro-tein(hs-CRP)and interleukin-6(IL-6)in catheter-related bloodstream infection (CRBSI)in patients in intensive care unit(ICU).Methods 78 ICU patients with suspected CRBSI between April 2013 and April 2015 were selected, blood specimens of patients on the first day of admission and being suspected CRBSI were taken,blood and venous catheter tips were performed culture,patients were divided into CRBSI group and non-CRBSI group according to culture results of blood and venous catheter tips,diagnostic values of PCT,hs-CRP,and IL-6 were compared. Results 28 patients were diagnosed CRBSI.On the day of being suspected with CRBSI,levels of PCT,hs-CRP, IL-6,and white blood cell (WBC)in CRBSI group were significantly higher than non-CRBSI group respectively ([3.35±1 .52]μg/L vs [1 .22±0.44]μg/L;[32.90 ±11 .10]mg/L vs [23.50 ±6.00]mg/L;[423.20 ±171 .70] ng/L vs [257.90±81 .40]ng/L;[12.70±2.70]×109/L vs [11 .20±1 .90]×109/L],P <0.05 ).The receiver op-erating characteristic curve(ROC)analysis showed that area under the curve (AUC)and 95% CI of PCT,hs-CRP, IL-6,and WBC were 0.92(0.85,0.99),0.75(0.62,0.88),0.80(0.67,0.92),and 0.64(0.50,0.72)respectively;sensitivity were 0.82,0.64,0.71 ,and 0.46 respectively;specificity were 0.92,0.94,0.92,and 0.88 respectively. Conclusion PCT and IL-6 have high effectiveness for early diagnosis of CRBSI in ICU patients,and have certain predictive value for early diagnosis of CRBSI.%目的：研究降钙素原（PCT）、高敏 C 反应蛋白（hs-CRP）、白介素6（IL-6）对重症监护病房（ICU）患者导管相关血流感染（CRBSI）早期诊断的临床价值。方法选择某院2013年4月—2015年4月 ICU 留置中心静脉导管（CVC）疑诊 CRBSI 的78例患者，患者入住 ICU 及疑诊 CRBSI 当日采集患者血液标本，同时行血培养和静脉导管尖端培养，根据血培养和静脉导管尖端培养结果将患者分为 CRBSI 组与非 CRBSI 组，比较 PCT、hs-CRP、IL-6对 CRBSI 诊断的价值。结果28例疑诊患者最终诊断为 CRBSI。疑诊 CRBIS 当日，CRBSI 组患者的 PCT、hs-CRP、IL-6和血白细胞（WBC）水平分别为（3．35±1．52）μg／L、（32．90±11．10）mg／L、（423．20±171．70）ng／L、和（12．70±2．70）×109／L，均高于非 CRBSI 组[分别为（1．22±0．44）μg／L、（23．50±6．00）mg／L、（257．90±81．40） ng／L、和（11．20±1．90）×109／L]，差异均有统计学意义（均 P ＜0．05）。ROC 曲线分析：PCT、hs-CRP、IL-6和血白细胞（WBC）水平曲线下面积（AUC）及95％ CI 分别为0．92（0．85，0．99）、0．75（0．62，0．88）、0．80（0．67，0．92）和0．64（0．50，0．72）；灵敏度分别为0．82、0．64、0．71和0．46；特异度分别为0．92、0．94、0．92和0．88。结论 PCT和 IL-6对 ICU 患者 CRBSI 的早期诊断具有较高的价值，对及早诊断 CRBSI 具有一定的预测作用。
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