Syk和VEGF-C在乳腺癌组织中的表达与淋巴结转移的关系

摘要

Objective:To explore the relationship of Syk and VEGF-C expression in breast cancer with lymph node metastasis . Methods:The expression of Syk and VEGF-C in 40 cases of breast cancer were determined using immunohistochemistry assay .Then, the positive rates of Syk and VEGF-C were compared with lymph node metastasis .Results:The expression rate of VEGF-C and Syk in breast cancer was respectively 77.5%(31/40), 37.5%(15/40).VEGF-C protein expression was not significant related with the tumor diameter (P>0.05) and histological grade (P>0.05), but was significantly associated with lymph node metastasis (P<0.05).Syk protein expression was not significant related with tumor diameter (P>0.05) and the histological grade(P>0.05), and was associated with lymph node metastasis (P<0.05).The difference of Syk and VEGF-C had statistics significance(P<0.05).Con-clusion:Syk and VEGF-C involved in the lymphatic invasion and metastasis , may be an important indicator of prognosis .%目的：探讨VEGF-C和Syk在乳腺癌中的表达与淋巴结转移的关系。方法：应用免疫组织化学方法，检测40例乳腺浸润性导管癌、10例乳腺纤维腺瘤、10例正常乳腺组织Syk和VEGF-C的表达，分析其与淋巴结转移的关系。结果：VEGF-C在正常乳腺组织、乳腺纤维腺瘤、乳腺癌中的阳性表达率分别为0％（0/10），30．0％（3/10），77．5％（31/40）；Syk在正常乳腺组织、乳腺纤维腺瘤、乳腺癌中的阳性表达率分别为100％（10/10），100％（10/10），37．5％（15/40）。 VEGF-C表达与肿瘤直径、组织学分级无显著相关（P＞0．05；P＞0．05），与淋巴结转移呈显著相关（P＜0．05）；Syk表达与肿瘤直径、组织学分级无显著相关（P＞0．05；P＞0．05），与淋巴结转移呈显著相关（P＜0．05）；Syk与VEGF-C间差异有统计学意义（P＜0．05）。结论：Syk和VEGF-C参与了乳腺癌的淋巴道浸润、转移，可能是判断预后的重要指标。