目的 观察冠状动脉内注射半剂量替罗非班对老年ST段抬高心肌梗死(STEMI)接受急诊PCI患者术中慢血流的有效性及安全性.方法 选择因STEMI住院行急诊PCI术,并于术中出现慢血流患者共217例,根据冠状动脉内应用替罗非班的剂量分为半剂量组(5 μg/kg)126例和常规剂量组(10 μg/kg)91例,比较2组一般临床特点,分析有效性及安全性.结果 半剂量组轻度出血比例明显低于常规剂量组(1.6％ vs 7.7％,P＜0.05).而2组患者LVEF、ST段回落、中度出血及院内病死率比较差异无统计学意义(P＞0.05).结论 针对老年STEMI患者的临床特点,急诊PCI过程中出现慢血流时选择冠状动脉内应用半剂量替罗非班安全、有效.%Objective To study the safety and effect of 50% tirofiban dose on slow flow in elderly patients with acute myocardial infarction(AMI) during emergency percutaneous coronary inter-vention(PCI). Methods Two hundred and seventeen AMI patients with slow flow during emergency PCI for ST-segment elevation were divided into 50% tirofiban dose (5 μg/kg) group (n = 126) and routine tirofiban dose(10 μg/kg) group. Their clinical features and the safety and effect of tirofiban were compared and analyzed. Results The incidence of mild bleeding was significantly lower in 50%tirofiban dose group than in routine tirofiban dose groupd. 6% vs 7. 7% ,P<0. 05). No significant difference was found in the LVEF, ST-segment resolution, moderate bleeding and in hospital death rate between the two groups(P>0. 05). Conclusion Intracoronary 50% tirofiban dose is safe and effective for slow flow in elderly AMI patients during emergency PCI.
展开▼
