Objective To investigate the effects of two kinds of anesthesia methods on immune function of patients with uterine cervical carcinoma after radical hysterectomy. Method 86 patients with uterine cervical carcinoma from December 2013 to December 2015 in our hospital were selected as objects of study, and they were randomly divided into observation group (43 cases) and control group (43 cases), all patients accepted radical hysterectomy. Observation group patients accepted general anesthesia combined with epidural block, while control group patients accepted general anesthesia. Cellular immunity, NK cells and stress related indicators during perioperative period between the two groups were compared. Result 2 hours after anesthesia and the 1st day after operation, levels of CD3+, CD4+, CD8+, CD4+/CD8+and NK cells were lower than before anesthesia (P<0.05), but the 3rd day and 7th day after operation, the levels of above indexes increased gradually. 2 hours after anesthesia, the 1st day and 3rd day after operation, levels of CD3+, CD4+, CD8+, CD4+/CD8+and NK cells were significantly higher than control group (P<0.05). The 7th day after operation, the levels of CD4+and CD8+were significantly higher than control group (P<0.05). 2 hours after anesthesia and the 1st day after operation, the levels of cortisol hydrocortisione and IL-6 level of the two groups were significantly increased than before anesthesia (P < 0.05), level of TNF-αwere lower than before anesthesia (P<0.05). 2 hours after anesthesia, the 1st day and 3rd day after operation, levels of cortisol hydrocortisione and IL-6 of observation group were lower than control group, level of TNF-αwere higherthan control group (P<0.05). Conclusion General anesthesia combined with epidural block can effectively counter the immune suppression caused by surgical stress, so as to reduce the adverse effects of surgery on the immune function of patients with uterine cervical carcinoma.%目的探讨两种麻醉方法对宫颈癌根治术患者免疫功能的影响。方法选取2013年12月至2015年12月就诊于本院的86例宫颈癌患者为研究对象，将其随机分为观察组（43例）和对照组（43例）。两组患者均行宫颈癌根治术。观察组患者采用全身麻醉联合硬膜外阻滞，对照组患者仅采用全身麻醉。比较两组患者围术期细胞免疫、自然杀伤细胞（NK细胞）及应激相关指标的差异。结果麻醉后2小时和术后第1天，两组患者T淋巴细胞亚群CD3+、CD4+、CD8+、CD4+/CD8+及NK细胞水平均明显低于麻醉前（P＜0.05），但术后第3天和第7天，两组患者上述指标水平均逐渐升高。麻醉后2小时、术后第1天及第3天，观察组患者CD3+、CD4+、CD8+、CD4+/CD8+及NK细胞水平均明显高于对照组（P＜0.05）。术后第7天，观察组患者CD4+和CD8+水平均明显高于对照组（P＜0.01）。麻醉后2小时和术后第1天，两组患者皮质醇和白介素-6（interleukin-6，IL-6）水平均明显高于麻醉前（P＜0.05），肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）水平明显低于麻醉前（P＜0.05）。麻醉后2小时、术后第1天和第3天，观察组患者皮质醇与IL-6水平均低于对照组（P＜0.05），而TNF-α水平高于对照组（P＜0.05）。结论全身麻醉联合硬膜外阻滞可有效对抗手术应激产生的免疫抑制，减轻手术对宫颈癌患者免疫功能的不利影响。
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