视网膜色素上皮细胞的损伤因素与治疗进展

摘要

Retinal pgment epithelial (RPE) cells plays a key role in maintaining the normal physiological function and structure of retina and choroids.However,RPE cells are vulnerably damaged by many detrimental factors,such as anoxia,physical and chemical elements,pharmic,immunizing factors and oxidant stress,etc.The damage of RPE cells lead to multiple eye diseases,and therefore cause severe abnormality of visual function.To understand the causative factors of RPE cell-related eye diseases is very important for the prevention and treatment of these diseases.Recently,many studies about damage factors and treatments for RPE cells have received more attention.This article reviews the advances in RPE cell-related eye diseases.%视网膜色素上皮(RPE)细胞在维持视网膜和脉络膜的正常功能和组织结构方面发挥重要作用,许多因素可导致RPE细胞的损伤,如缺氧、物理因素、化学物质和药物、免疫因素、氧化应激等.RPE细胞的损伤可导致多种眼底疾病,引起视功能的损害或丧失.深入研究引起RPE细胞损伤的因素对各种RPE细胞相关性眼病的预防和治疗具有十分重要的意义.近年来相关的研究日益受到关注,对RPE细胞损伤的影响因素及治疗方法进行综述.