冠状动脉旁路移植术中经静脉桥血管注射尼卡地平后桥血管流量的影响研究

摘要

目的 探讨冠状动脉(冠脉)旁路移植术中经静脉桥血管注射尼卡地平后桥血管流量的影响.方法 回顾性分析2017年5月至2017年8月于阜外医院心外科一个病区行冠脉旁路移植术中经静脉桥注射尼卡地平后患者桥血管流量的变化.结果 经静脉桥血管注射尼卡地平患者共计87例,其中男性76例,女性11例,年龄在39~83岁之间,平均年龄为(63.4±10.0)岁.尼卡地平经静脉桥注射前、后静脉桥血管平均流量分别为(33.7±8.7)ml/min、(56.2±15.3)ml/min(n=195,P＜0.05);左胸廓内动脉桥血管平均流量前后分别为(24.8±6.8)ml/min、(34.6±7.6)ml/min(n=85,P＜0.05).体外循环与非体外循环分组经静脉桥血管注射尼卡地平后桥血管流量变化无明显差异(P＞0.05).冠脉非弥漫病变组与弥漫病变组分组经静脉桥血管注射尼卡地平后桥血管流量变化无明显差异(P＞0.05).结论 冠脉旁路移植术中经静脉桥注射尼卡地平后患者桥血管流量明显增加.经桥血管注射尼卡地平是一种冠脉旁路移植术中改善桥血管流量简易、安全、有效的治疗方法.%Objective To investigate the influence of intravascular injection of nicardipine via vein graft on graft flow during coronary artery bypass grafting (CABG). Methods A retrospective analysis was conducted in one inpatient ward in Department of Cardiac Surgery in Beijing Fuwai Hospital from May 2017 to Aug. 2017. The changes of graft flow were observed in the patients after intravascular injection of nicardipine via vein graft during CABG. Results There were totally 87 patients with intravascular injection of nicardipine via vein graft, and among them 76 were the male and 11 were the female aged from 39 to 83 (average age=63.4±10.0). The mean vein graft flow was (33.7±8.7) ml/min before nicardipine injection and (56.2±15.3) ml/min after nicardipine injection (n=195, P0.05). The changes of graft flow had no significant difference between non-diffuse coronary lesion group and diffuse coronary lesion group after nicardipine injection (P>0.05). Conclusion The graft flow is improved significantly in patients after intravascular injection of nicardipine via vein graft during CABG. Therefore the intravascular injection of nicardipine via vein graft is a simple, safe and effective therapy for improving graft flow during CABG.