Objective To investigate the correlation between pulse wave velocity and cardiovascular diseases and their risk factors in elderly population. Methods Cluster sampling method was used to select 1701 people who were equal to or over 70 years old ( average age: 73.8 ) , and then they were given questionnaire survey, physical examination and laboratory tests. The level of carotid—femoral pulse wave velocity ( cfPWV ) was detected by applying French Complior SP, and the relationship between cfPWV and hypertension and their risk factors was observed. Results The level of cfPWV increased along with the increase of blood pressure, and was significantly higher in the patients with hypertension, brain stroke, myocardial infarction and diabetes than that in normal population with statistical difference. The results of multivariate regression analysis showed that age, male sex, mean arterial pressure, heart rate and insulin resistance index were correlated to cfPWV ( P<0.001 ) , and was negatively correlated to body mass index in whole population and the patients with brain stroke, myocardial infarction and diabetes. Conclusion The level of cfPWV is closely related to hypertension and risk factors of cardiovascular disease in elder population.%目的 探讨老年人群脉搏波速度(PWV)与心血管病及危险因素的相关性.方法 采用整群抽样方法纳入≥70岁人群1701例,进行问卷调查、体格检查和实验室检验,测量颈-股动脉脉搏波速度(cfPWV),观察cfPWV与高血压及相关危险因素的关系.结果 cfPWV 水平随血压水平升高而升高,在高血压、脑卒中、心肌梗死和糖尿病患者中cfPWV明显高于正常人群,差异有统计学意义.多元逐步回归分析显示在入选者和脑卒中、心肌梗死和糖尿病人群中,年龄、男性、平均动脉压、心率、胰岛素抵抗指数(Homa IR)与cfPWV呈正相关(P＜0.001),体重指数与cfPWV负相关.结论 在老年人群中,cfPWV与高血压及心血管病危险因素密切相关.
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