原发性高血压患者肱踝动脉脉搏波传导速度与心血管危险因素的相关性分析

摘要

Objective:To investigate the correlationship between early morning blood pressure ,brachial‐ankle artery pulse wave velocity (baPWV ) and risk factors of cardiovascular diseases (early morning blood ,blood lipid ,blood glucose , homocysteine [HCY] ,glomerular filtration rate [eGFR] ,carotid artery plaque) .Methods:Early morning blood pressure was monitored in 297 patients with primary hypertension ,and baPWV ,blood lipid ,blood glucose ,HCY ,eGFR and carotid artery color Doppler were examined .SAS 9 .2 was used to analyze the relationship between baPWV and early morning blood pressure , blood lipid ,blood glucose ,HCY ,carotid plaque and age .The independent risk factors of baPWV were analyzed by regression analysis (Stepwise) .Results:BaPWV was significantly correlated with age ,early morning blood pressure ,low density lipoprotein cholesterol (LDL‐C) ,eGFR and carotid artery plaque (P< 0 .05) .BaPWV was not significantly correlated with fasting glucose or HCY .The regression analysis showed that the early morning blood pressure ,LDL‐C and carotid artery plaque were the independent risk factors of baPWV ( P < 0 .05 ) . Conclusions: The early morning hypertension and hypercholesteremia are correlated with arteriosclerosis in patients with essential hypertension .%目的：探讨原发性高血压患者肱踝动脉脉搏波传导速度（brachial‐ankle artery pulse wave velocity ，baPWV）与心血管疾病危险因素的相关性。方法：监测297例原发性高血压患者清晨血压水平，同时检测其baPWV、血脂、血糖、同型半胱氨酸（homocysteine ，HCY）、肾小球滤过率（eGFR）等指标，并进行颈动脉彩超检查。采用SAS 9．2对baPWV与清晨血压、血脂、血糖、HCY、颈动脉斑块、患者年龄进行相关性分析。采用Stepwise对baPWV的独立影响因素进行回归分析。结果：baPWV与患者年龄、清晨血压水平、低密度脂蛋白胆固醇（LDL‐C）浓度、肾小球滤过率（eGFR）、颈动脉斑块的形成相关（P＜0．05），与空腹血糖、HCY浓度无明显相关。回归分析显示，清晨血压水平、LDL‐C浓度、颈动脉斑块的形成是baPWV的独立影响因素（P＜0．05）。结论：原发性高血压患者清晨血压升高、高胆固醇血症与动脉硬化显著相关。