维生素D受体基因CDX2多态性与阿达木单抗治疗中重度斑块型银屑病疗效相关性研究

摘要

Objective To study the association between vitamin D receptor (VDR) gene CDX2 polymorphism and response to Adalimumab treatment of plaque psoriasis, in order to predict the outcomes of biologics in treating psoriasis. Methods By high-throughput SNP sequencing technique, the SNPs of VDR gene locus CDX2 of two groups of patients who were divided by whether they've achieved PASI75 after 12 weeks' treatment were examined. And the allelic frequencies and genotypic frequencies between the two groups were compared byχ2 test. Results The allelic frequencies and genotypic frequencies of VDR gene locus CDX2 between the two groups had no statistical significance (P>0.05). Conclusion There is no association between vitamin D receptor gene CDX2 polymorphism and response to Adalimumab treatment of plaque psoriasis.%目的 探讨维生素D受体(VDR)基因位点多态性与阿达木单抗治疗斑块型银屑病疗效的关联性,以期对生物制剂治疗银屑病效果进行预测.方法 采用中高通量单核苷酸多态性(SNP)分型技术,对达到和未达到银屑病面积与严重程度指数改善75%(PASI75) 的2组患者VDR基因CDX2(rs11568820) 位点多态性进行检测, 比较2组CDX2基因型和等位基因分布频率差异. 结果 有效组和无效组VDR基因CDX2位点的基因型和等位基因的分布频率相比差异均无统计学意义(P>0.05). 结论 VDR基因CDX2位点多态性与阿达木单抗治疗中重度斑块型银屑病疗效无相关性.