miRNAs是一类内源性的非编码小分子RNA，它能降解靶mRNAs或阻遏其翻译过程。在神经胶质瘤中，有些miRNAs表达水平是上调的，而有些则是下调的；有些miRNAs在肿瘤发生发展过程中起促进作用，而有些则发挥着类似抑癌基因的功能。因此，研究神经胶质瘤中miRNAs的表达概况，既可以为临床上胶质瘤的早期诊断提供辅助依据，还可以提供新的治疗策略。本文将就miRNAs在胶质瘤中表达水平及作用靶点的研究作一综述。%miRNAs are a class of small endogenous RNAs that degrade target mRNAs or repress their translation process. Several miRNAs in glioma are up⁃regulated, while some others down⁃regulated. Some miRNAs promote tumorigenesis; some others, however, play a similar function of tumor suppressor genes. Therefore, studies on the expression profiles of miRNAs in glioma may afford auxiliary basis for early clinical diagnosis and novel srtategies for therapy of glioma. This paper will review on researches about the expression levels of miRNAs and their targets in glioma.
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